Historically, the number of perturbations sampled was much smaller than the number of cell observations.

“But when they had like in a single experiment, ten million transcriptomes measured, right? I thought that was like, like next level stuff and, you know, this step from just getting more PBMCs as a control to like, let's actually do something at scale to it, sort of having here the cell space, but then having here the perturbation space, which typically was very scarce.”

“It was like control versus disease or so. So this sort of number of points, what you had here in terms of sampling on the perturbation space was typically much, much more scarce than the number of observations in terms of cells that you had.”