SPEAKER_02 says substantial changes in atomic geometry usually produce substantial changes in the XRD pattern.

“raise the temperature or do something else to encourage them to react and then atoms start reacting and they form into this new crystal and this shows up in the XRD pattern because usually if the geometry of the atoms change drastically the XRD pattern changes a lot but what really happens in like a typical practical materials discovery campaign is when you first try something it doesn't work and the outcome isn't just like a clear yes or no but it's usually like a very mixed”